The 150+ test list.
Our methodology integrates insights from five key pillars, assessing your current state and customizing interventions to optimize your body's innate potential for resilience and well-being.
Foundational Health Panel:Blood-Based Biomarkers
This panel provides a comprehensive snapshot of current physiological status, covering key areas like heart, metabolic, hormonal, and organ health.
Heart Health
Apolipoprotein B (apoB)
More accurate predictor of cardiovascular disease risk than LDL-cholesterol alone
HDL-Cholesterol
"Good" cholesterol; protective against heart disease
LDL-Cholesterol
"Bad" cholesterol; high levels increase heart disease risk
Lipoprotein (a) [Lp(a)]
Genetically determined particle strongly linked to cardiovascular and heart valve disease risk
Non-HDL Cholesterol
Represents all atherogenic lipoproteins; strong predictor of heart disease risk
TG:HDL-C ratio
Higher ratio associated with insulin resistance and increased heart disease risk
Total Cholesterol
Overall measure of blood cholesterol
Triglycerides
High levels increase risk of heart disease and pancreatitis
Energy Metabolism
Estimated Average Glucose (eAG)
Reflects average blood glucose over past 2-3 months
Fasting glucose
Essential for diagnosing and monitoring diabetes/pre-diabetes
Fasting insulin
High levels can indicate insulin resistance
Ferritin
Iron storage protein; indicates iron status
HbA1c (Glycated Hemoglobin)
Key for diagnosing and managing diabetes (average 2-3 month glucose)
HOMA-IR
Estimates insulin resistance, assessing metabolic health
Uric Acid
High levels linked to gout, kidney stones, and may contribute to cardiovascular/metabolic diseases
Hormonal Health
Cortisol
Primary stress hormone; chronic elevation impacts multiple systems and can accelerate aging
Cortisol:DHEA-S Ratio
Assesses balance between stress and protective hormones; indicator of adrenal health
DHEA-S
Precursor hormone; levels decline with age/stress, impacting vitality
Estradiol (E2)
Primary estrogen; crucial for reproductive, bone, cardiovascular, and cognitive health
Follicle-Stimulating Hormone (FSH)
Regulates reproductive functions; levels change with menopause/aging
Free Testosterone
Biologically active testosterone; influences libido, muscle, bone, mood, energy
Free Testosterone:Cortisol ratio
Reflects anabolic/catabolic balance; important for stress and recovery assessment
Free Thyroxine (T4)
Thyroid hormone essential for metabolism and energy
Luteinizing Hormone (LH)
Key for reproductive health and hormonal balance
Progesterone
Involved in menstrual cycle, pregnancy, mood, sleep, bone health
Sex Hormone Binding Globulin (SHBG)
Regulates availability of sex hormones to tissues
Thyroid Stimulating Hormone (TSH)
Primary screening for thyroid disorders
Total Testosterone
Overall assessment of testosterone levels
Triiodothyronine (T3), Free
Active thyroid hormone; influences metabolism, heart rate, energy
Nutrients Vitamins Minerals
Calcium
Essential for bone, muscle, nerve function
Corrected Calcium
More accurate measure of biologically active calcium
Folate (Vitamin B9)
Crucial for DNA synthesis, cell division; deficiency linked to high homocysteine
Homocysteine
Elevated levels are a risk factor for cardiovascular disease, stroke, cognitive decline
Iron Saturation
Helps diagnose iron deficiency or overload
Magnesium, RBC
More accurate indicator of body's magnesium stores; vital for many functions
Total Iron Binding Capacity (TIBC)
High TIBC suggests iron deficiency
Unsaturated Iron Binding Capacity (UIBC)
Low UIBC can indicate iron overload
Vitamin B12
Essential for nerve function, DNA synthesis; deficiency more common with age
Vitamin D (25-hydroxyvitamin D)
Crucial for bone health, immune function, inflammation regulation
Kidney Health
BUN (Blood Urea Nitrogen)
Elevated levels can indicate impaired kidney function
BUN/Creatinine Ratio
Helps determine cause of kidney dysfunction
Creatinine
Elevated serum levels indicate reduced kidney function
Cystatin C
Sensitive marker of early kidney dysfunction
Estimated Glomerular Filtration Rate (eGFRcr & eGFRcr-cys)
Estimates kidney filtration capability
Potassium
Crucial for nerve/muscle function; regulated by kidneys
Sodium
Essential for fluid balance, nerve/muscle function; regulated by kidneys
Urine Albumin/Creatinine Ratio (uACR)
Early and sensitive marker of kidney damage
Liver Health
Alanine Transaminase (ALT)
Elevated levels often indicate liver cell damage
Albumin
Main blood protein; low levels can indicate liver disease, malnutrition
Alkaline Phosphatase (ALP)
Elevated levels can indicate liver or bone disorders
Aspartate Transaminase (AST)
Elevated levels can indicate liver, muscle, or heart damage
Direct Bilirubin
Elevated levels suggest impaired bile flow or liver dysfunction
Fibrosis-4 Index (FIB-4)
Estimates degree of liver fibrosis (scarring)
Gamma-glutamyl Transferase (GGT)
Sensitive to liver damage, particularly from alcohol/drugs
Total Bilirubin
High levels can indicate liver disease, bile duct obstruction, or hemolysis
Total Protein
Reflects nutritional status and can indicate liver or kidney disease
Inflammation Immunity
Erythrocyte Sedimentation Rate (ESR)
Non-specific marker of inflammation
High-Sensitivity C-Reactive Protein (hsCRP)
Sensitive marker for chronic low-grade inflammation; linked to cardiovascular and other chronic disease risk
Blood Health
Complete Blood Count (CBC) with differential
Comprehensive assessment of blood cells, indicating oxygen-carrying capacity, immune status, infection, anemia, and clotting potential
Iron
Essential mineral for hemoglobin and oxygen transport
Cancer Screening Male
Free PSA
Helps distinguish prostate cancer from benign conditions in men with elevated Total PSA
Prostate Specific Antigen (PSA), Total
Elevated levels may indicate prostate issues in men
Urine Analysis
Comprehensive Urine Analysis
Provides insights into kidney function, hydration, metabolic state, and potential infections
Genetic Blueprint Panel: Exome Sequencing Key Genes
This panel focuses on genes and variants with established links to longevity, healthy aging, or significant risk for age-related diseases. Exome sequencing can identify these and other relevant variants
Longevity Genes
APOE
Major influence on Alzheimer's risk, cardiovascular health, and longevity
FOXO3
Consistently associated with increased longevity across diverse populations
IGF-1 Axis (e.g., IGF-1, GHR)
Variants linked to exceptional longevity and protection from age-related diseases
Sirtuins (e.g., SIRT1, SIRT3, SIRT6)
Involved in cellular health, stress response, metabolism; variants linked to healthy aging or disease risk
BPIFB4
Enriched in centenarians, promotes healthier aging, reduces chronic disease risk
ATM
DNA damage response; variants linked to reduced lifespan and increased cancer risk
BRCA1 / BRCA2
DNA repair; variants significantly increase risk of several cancers
TTN
Muscle protein; variants are a common cause of dilated cardiomyopathy
NF-κB Pathway Genes (e.g., NFKB1, RELA, NFKBIA)
Key inflammatory pathway; variants and pathway dysregulation linked to aging and age-related diseases
Nutrigenomic Genes
ADRB2
May influence carbohydrate metabolism and risk of type 2 diabetes/obesity
PPARG
May influence insulin sensitivity and protect against obesity/diabetes
ACMG Secondary Findings
ACMG SF v3.2 Genes (Selected)
Includes genes where variants are associated with medically actionable conditions (e.g., inherited cancer predispositions, cardiovascular risks)
Gut Health & Systemic Impact Panel: Metagenome Sequencing
This panel assesses the gut microbiome's composition and functional potential, which are crucial for inflammation, immunity, and overall health.
Diversity & Composition
Alpha Diversity (e.g., Shannon Index, Richness)
Higher diversity generally linked to gut health and resilience; patterns vary with healthy aging
Beta Diversity (Uniqueness)
Increasing uniqueness with age is a hallmark of healthy aging and predicts survival
Key Bacterial Taxa
Akkermansia muciniphila
Associated with healthy aging, gut barrier integrity, reduced inflammation, metabolic health
Faecalibacterium prausnitzii
Major butyrate producer, anti-inflammatory; important for gut health
Christensenellaceae family
Associated with leanness and healthy aging; enriched in centenarians
Bifidobacterium spp.
Generally beneficial; associated with healthy aging in some cohorts
Ruminococcaceae / Lachnospiraceae families
Key SCFA producers; abundant in healthy individuals
Bacteroides spp. (specific species balance)
Core genus; specific shifts (e.g., B. fragilis enrichment) linked to healthy aging
Desulfovibrio piger
Enriched in centenarians, potentially anti-inflammatory
Clostridium hathewayi (levels)
Elevated levels may be linked to gut permeability and inflammation
Escherichia spp. (levels)
Increase often seen with aging/dysbiosis; can be pro-inflammatory
Microbial Metabolites
Short-Chain Fatty Acids (SCFAs: Butyrate, Propionate, Acetate)
Crucial for colonocyte energy, gut barrier, immune regulation, anti-inflammatory effects
Urolithin A (production potential)
Postbiotic from ellagitannins; promotes mitochondrial health, muscle function, anti-inflammatory
Equol (production potential)
Postbiotic from soy isoflavones; phytoestrogenic, antioxidant, potential anti-inflammatory benefits
Indole & Tryptophan Derivatives
Linked to reduced inflammation, improved gut barrier, and fitness in older adults
Secondary Bile Acids (specific profile)
Certain profiles enriched in centenarians; may protect against infection, maintain gut homeostasis
p-Cresol (levels)
Elevated levels linked to renal impairment, frailty; negative association with longevity
Trimethylamine N-oxide (TMAO) (levels/production potential)
High levels associated with increased cardiovascular disease risk
Biological Age Panel: Methylation Analysis (Epigenetic Clocks)
This panel uses DNA methylation patterns to estimate biological age and the pace of aging, offering insights beyond chronological age.
PhenoAge (DNAm PhenoAge)
Phenotypic Age / Healthspan Predicts mortality, morbidity, functional decline; reflects immune aging and metabolic stress
GrimAge (DNAm GrimAge)
Mortality Risk / Healthspan Highly predictive of time-to-death, cardiovascular events, cancer; linked to inflammation and hematopoietic aging
DunedinPACE
Pace of Biological Aging Measures current rate of multi-system biological aging; sensitive to interventions and lifestyle changes
Horvath Clock / Hannum Clock
Chronological Age Estimation Foundational age estimators; deviations can indicate accelerated/decelerated aging, though less predictive of health outcomes than newer clocks
EpiScores (various)
Specific Health Risks / Physiological States Targeted methylation scores for inflammation, glycemic control, immunosenescence, specific disease risks
Personalized Medication Panel: Pharmacogenomics (PgX)
This panel identifies genetic variants that influence response to common medications, aiming to optimize efficacy and minimize adverse drug reactions. This is particularly important for managing age-related conditions and polypharmacy.
CYP2D6
Variants: Poor, Intermediate, Ultrarapid Metabolizer Alleles Drugs: Codeine, Tramadol, Tamoxifen, Antidepressants (e.g., amitriptyline, paroxetine), Beta-blockers Optimizes pain management, cancer therapy, psychiatric medication by predicting efficacy/toxicity
CYP2C19
Variants: Loss-of-function (*2, *3), Gain-of-function (*17) Alleles Drugs: Clopidogrel, Proton pump inhibitors (e.g., omeprazole), Some antidepressants (e.g., citalopram) Optimizes antiplatelet therapy (critical for cardiovascular health), acid suppression, psychiatric treatment
CYP2C9
Variants: Decreased function Alleles (*2, *3) Drugs: Warfarin, NSAIDs (e.g., ibuprofen, celecoxib), Phenytoin, Fluvastatin Optimizes anticoagulation, pain/inflammation management, seizure control; impacts statin exposure
SLCO1B1
Variants: c.521T>C (rs4149056) (decreased function) Drugs: Statins (simvastatin, atorvastatin, rosuvastatin etc.) Guides statin choice/dose to prevent myopathy by predicting risk of SAMS
ABCG2
Variants: c.421C>A (rs2231142) (poor function) Drugs: Rosuvastatin Guides rosuvastatin dosing to balance efficacy and safety, especially in certain ancestries
VKORC1
Variants: -1639G>A (rs9923231) (altered sensitivity) Drugs: Warfarin Used in dosing algorithms to achieve therapeutic anticoagulation and reduce bleeding/clotting risk
DPYD
Variants: Variants causing decreased/absent function Drugs: Fluoropyrimidines (5-fluorouracil, capecitabine) Prevents severe, life-threatening toxicity from common chemotherapy agents
TPMT & NUDT15
Variants: Variants causing decreased/absent function Drugs: Thiopurines (azathioprine, mercaptopurine) Guides dosing to prevent severe myelosuppression from immunosuppressants/chemotherapy
HLA-B
Variants: HLA-B*57:01 Drugs: Abacavir Prevents severe hypersensitivity reaction to HIV medication
HLA-B
Variants: HLA-B*58:01 Drugs: Allopurinol Reduces risk of severe cutaneous adverse reactions to gout medication
HLA-B
Variants: HLA-B*15:02 Drugs: Carbamazepine, Oxcarbazepine, Phenytoin Reduces risk of SJS/TEN from antiepileptic drugs, especially in Asian populations
MT-RNR1
Variants: m.1555A>G Drugs: Aminoglycoside antibiotics (gentamicin, tobramycin) Prevents irreversible hearing loss (ototoxicity) from common antibiotics