The 150+ test list.

Our methodology integrates insights from five key pillars, assessing your current state and customizing interventions to optimize your body's innate potential for resilience and well-being.

Foundational Health Panel:Blood-Based Biomarkers

This panel provides a comprehensive snapshot of current physiological status, covering key areas like heart, metabolic, hormonal, and organ health.

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Heart Health

Apolipoprotein B (apoB)

More accurate predictor of cardiovascular disease risk than LDL-cholesterol alone

HDL-Cholesterol

"Good" cholesterol; protective against heart disease

LDL-Cholesterol

"Bad" cholesterol; high levels increase heart disease risk

Lipoprotein (a) [Lp(a)]

Genetically determined particle strongly linked to cardiovascular and heart valve disease risk

Non-HDL Cholesterol

Represents all atherogenic lipoproteins; strong predictor of heart disease risk

TG:HDL-C ratio

Higher ratio associated with insulin resistance and increased heart disease risk

Total Cholesterol

Overall measure of blood cholesterol

Triglycerides

High levels increase risk of heart disease and pancreatitis

Energy Metabolism

Estimated Average Glucose (eAG)

Reflects average blood glucose over past 2-3 months

Fasting glucose

Essential for diagnosing and monitoring diabetes/pre-diabetes

Fasting insulin

High levels can indicate insulin resistance

Ferritin

Iron storage protein; indicates iron status

HbA1c (Glycated Hemoglobin)

Key for diagnosing and managing diabetes (average 2-3 month glucose)

HOMA-IR

Estimates insulin resistance, assessing metabolic health

Uric Acid

High levels linked to gout, kidney stones, and may contribute to cardiovascular/metabolic diseases

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Hormonal Health

Cortisol

Primary stress hormone; chronic elevation impacts multiple systems and can accelerate aging

Cortisol:DHEA-S Ratio

Assesses balance between stress and protective hormones; indicator of adrenal health

DHEA-S

Precursor hormone; levels decline with age/stress, impacting vitality

Estradiol (E2)

Primary estrogen; crucial for reproductive, bone, cardiovascular, and cognitive health

Follicle-Stimulating Hormone (FSH)

Regulates reproductive functions; levels change with menopause/aging

Free Testosterone

Biologically active testosterone; influences libido, muscle, bone, mood, energy

Free Testosterone:Cortisol ratio

Reflects anabolic/catabolic balance; important for stress and recovery assessment

Free Thyroxine (T4)

Thyroid hormone essential for metabolism and energy

Luteinizing Hormone (LH)

Key for reproductive health and hormonal balance

Progesterone

Involved in menstrual cycle, pregnancy, mood, sleep, bone health

Sex Hormone Binding Globulin (SHBG)

Regulates availability of sex hormones to tissues

Thyroid Stimulating Hormone (TSH)

Primary screening for thyroid disorders

Total Testosterone

Overall assessment of testosterone levels

Triiodothyronine (T3), Free

Active thyroid hormone; influences metabolism, heart rate, energy

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Nutrients Vitamins Minerals

Calcium

Essential for bone, muscle, nerve function

Corrected Calcium

More accurate measure of biologically active calcium

Folate (Vitamin B9)

Crucial for DNA synthesis, cell division; deficiency linked to high homocysteine

Homocysteine

Elevated levels are a risk factor for cardiovascular disease, stroke, cognitive decline

Iron Saturation

Helps diagnose iron deficiency or overload

Magnesium, RBC

More accurate indicator of body's magnesium stores; vital for many functions

Total Iron Binding Capacity (TIBC)

High TIBC suggests iron deficiency

Unsaturated Iron Binding Capacity (UIBC)

Low UIBC can indicate iron overload

Vitamin B12

Essential for nerve function, DNA synthesis; deficiency more common with age

Vitamin D (25-hydroxyvitamin D)

Crucial for bone health, immune function, inflammation regulation

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Kidney Health

BUN (Blood Urea Nitrogen)

Elevated levels can indicate impaired kidney function

BUN/Creatinine Ratio

Helps determine cause of kidney dysfunction

Creatinine

Elevated serum levels indicate reduced kidney function

Cystatin C

Sensitive marker of early kidney dysfunction

Estimated Glomerular Filtration Rate (eGFRcr & eGFRcr-cys)

Estimates kidney filtration capability

Potassium

Crucial for nerve/muscle function; regulated by kidneys

Sodium

Essential for fluid balance, nerve/muscle function; regulated by kidneys

Urine Albumin/Creatinine Ratio (uACR)

Early and sensitive marker of kidney damage

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Liver Health

Alanine Transaminase (ALT)

Elevated levels often indicate liver cell damage

Albumin

Main blood protein; low levels can indicate liver disease, malnutrition

Alkaline Phosphatase (ALP)

Elevated levels can indicate liver or bone disorders

Aspartate Transaminase (AST)

Elevated levels can indicate liver, muscle, or heart damage

Direct Bilirubin

Elevated levels suggest impaired bile flow or liver dysfunction

Fibrosis-4 Index (FIB-4)

Estimates degree of liver fibrosis (scarring)

Gamma-glutamyl Transferase (GGT)

Sensitive to liver damage, particularly from alcohol/drugs

Total Bilirubin

High levels can indicate liver disease, bile duct obstruction, or hemolysis

Total Protein

Reflects nutritional status and can indicate liver or kidney disease

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Inflammation Immunity

Erythrocyte Sedimentation Rate (ESR)

Non-specific marker of inflammation

High-Sensitivity C-Reactive Protein (hsCRP)

Sensitive marker for chronic low-grade inflammation; linked to cardiovascular and other chronic disease risk

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Blood Health

Complete Blood Count (CBC) with differential

Comprehensive assessment of blood cells, indicating oxygen-carrying capacity, immune status, infection, anemia, and clotting potential

Iron

Essential mineral for hemoglobin and oxygen transport

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Cancer Screening Male

Free PSA

Helps distinguish prostate cancer from benign conditions in men with elevated Total PSA

Prostate Specific Antigen (PSA), Total

Elevated levels may indicate prostate issues in men

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Urine Analysis

Comprehensive Urine Analysis

Provides insights into kidney function, hydration, metabolic state, and potential infections

Genetic Blueprint Panel: Exome Sequencing Key Genes

This panel focuses on genes and variants with established links to longevity, healthy aging, or significant risk for age-related diseases. Exome sequencing can identify these and other relevant variants

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Longevity Genes

APOE

Major influence on Alzheimer's risk, cardiovascular health, and longevity

FOXO3

Consistently associated with increased longevity across diverse populations

IGF-1 Axis (e.g., IGF-1, GHR)

Variants linked to exceptional longevity and protection from age-related diseases

Sirtuins (e.g., SIRT1, SIRT3, SIRT6)

Involved in cellular health, stress response, metabolism; variants linked to healthy aging or disease risk

BPIFB4

Enriched in centenarians, promotes healthier aging, reduces chronic disease risk

ATM

DNA damage response; variants linked to reduced lifespan and increased cancer risk

BRCA1 / BRCA2

DNA repair; variants significantly increase risk of several cancers

TTN

Muscle protein; variants are a common cause of dilated cardiomyopathy

NF-κB Pathway Genes (e.g., NFKB1, RELA, NFKBIA)

Key inflammatory pathway; variants and pathway dysregulation linked to aging and age-related diseases

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Nutrigenomic Genes

ADRB2

May influence carbohydrate metabolism and risk of type 2 diabetes/obesity

PPARG

May influence insulin sensitivity and protect against obesity/diabetes

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ACMG Secondary Findings

ACMG SF v3.2 Genes (Selected)

Includes genes where variants are associated with medically actionable conditions (e.g., inherited cancer predispositions, cardiovascular risks)

Gut Health & Systemic Impact Panel: Metagenome Sequencing

This panel assesses the gut microbiome's composition and functional potential, which are crucial for inflammation, immunity, and overall health.

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Diversity & Composition

Alpha Diversity (e.g., Shannon Index, Richness)

Higher diversity generally linked to gut health and resilience; patterns vary with healthy aging

Beta Diversity (Uniqueness)

Increasing uniqueness with age is a hallmark of healthy aging and predicts survival

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Key Bacterial Taxa

Akkermansia muciniphila

Associated with healthy aging, gut barrier integrity, reduced inflammation, metabolic health

Faecalibacterium prausnitzii

Major butyrate producer, anti-inflammatory; important for gut health

Christensenellaceae family

Associated with leanness and healthy aging; enriched in centenarians

Bifidobacterium spp.

Generally beneficial; associated with healthy aging in some cohorts

Ruminococcaceae / Lachnospiraceae families

Key SCFA producers; abundant in healthy individuals

Bacteroides spp. (specific species balance)

Core genus; specific shifts (e.g., B. fragilis enrichment) linked to healthy aging

Desulfovibrio piger

Enriched in centenarians, potentially anti-inflammatory

Clostridium hathewayi (levels)

Elevated levels may be linked to gut permeability and inflammation

Escherichia spp. (levels)

Increase often seen with aging/dysbiosis; can be pro-inflammatory

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Microbial Metabolites

Short-Chain Fatty Acids (SCFAs: Butyrate, Propionate, Acetate)

Crucial for colonocyte energy, gut barrier, immune regulation, anti-inflammatory effects

Urolithin A (production potential)

Postbiotic from ellagitannins; promotes mitochondrial health, muscle function, anti-inflammatory

Equol (production potential)

Postbiotic from soy isoflavones; phytoestrogenic, antioxidant, potential anti-inflammatory benefits

Indole & Tryptophan Derivatives

Linked to reduced inflammation, improved gut barrier, and fitness in older adults

Secondary Bile Acids (specific profile)

Certain profiles enriched in centenarians; may protect against infection, maintain gut homeostasis

p-Cresol (levels)

Elevated levels linked to renal impairment, frailty; negative association with longevity

Trimethylamine N-oxide (TMAO) (levels/production potential)

High levels associated with increased cardiovascular disease risk

Biological Age Panel: Methylation Analysis (Epigenetic Clocks)

This panel uses DNA methylation patterns to estimate biological age and the pace of aging, offering insights beyond chronological age.

PhenoAge (DNAm PhenoAge)

Phenotypic Age / Healthspan Predicts mortality, morbidity, functional decline; reflects immune aging and metabolic stress

GrimAge (DNAm GrimAge)

Mortality Risk / Healthspan Highly predictive of time-to-death, cardiovascular events, cancer; linked to inflammation and hematopoietic aging

DunedinPACE

Pace of Biological Aging Measures current rate of multi-system biological aging; sensitive to interventions and lifestyle changes

Horvath Clock / Hannum Clock

Chronological Age Estimation Foundational age estimators; deviations can indicate accelerated/decelerated aging, though less predictive of health outcomes than newer clocks

EpiScores (various)

Specific Health Risks / Physiological States Targeted methylation scores for inflammation, glycemic control, immunosenescence, specific disease risks

Personalized Medication Panel: Pharmacogenomics (PgX)

This panel identifies genetic variants that influence response to common medications, aiming to optimize efficacy and minimize adverse drug reactions. This is particularly important for managing age-related conditions and polypharmacy.

CYP2D6

Variants: Poor, Intermediate, Ultrarapid Metabolizer Alleles Drugs: Codeine, Tramadol, Tamoxifen, Antidepressants (e.g., amitriptyline, paroxetine), Beta-blockers Optimizes pain management, cancer therapy, psychiatric medication by predicting efficacy/toxicity

CYP2C19

Variants: Loss-of-function (*2, *3), Gain-of-function (*17) Alleles Drugs: Clopidogrel, Proton pump inhibitors (e.g., omeprazole), Some antidepressants (e.g., citalopram) Optimizes antiplatelet therapy (critical for cardiovascular health), acid suppression, psychiatric treatment

CYP2C9

Variants: Decreased function Alleles (*2, *3) Drugs: Warfarin, NSAIDs (e.g., ibuprofen, celecoxib), Phenytoin, Fluvastatin Optimizes anticoagulation, pain/inflammation management, seizure control; impacts statin exposure

SLCO1B1

Variants: c.521T>C (rs4149056) (decreased function) Drugs: Statins (simvastatin, atorvastatin, rosuvastatin etc.) Guides statin choice/dose to prevent myopathy by predicting risk of SAMS

ABCG2

Variants: c.421C>A (rs2231142) (poor function) Drugs: Rosuvastatin Guides rosuvastatin dosing to balance efficacy and safety, especially in certain ancestries

VKORC1

Variants: -1639G>A (rs9923231) (altered sensitivity) Drugs: Warfarin Used in dosing algorithms to achieve therapeutic anticoagulation and reduce bleeding/clotting risk

DPYD

Variants: Variants causing decreased/absent function Drugs: Fluoropyrimidines (5-fluorouracil, capecitabine) Prevents severe, life-threatening toxicity from common chemotherapy agents

TPMT & NUDT15

Variants: Variants causing decreased/absent function Drugs: Thiopurines (azathioprine, mercaptopurine) Guides dosing to prevent severe myelosuppression from immunosuppressants/chemotherapy

HLA-B

Variants: HLA-B*57:01 Drugs: Abacavir Prevents severe hypersensitivity reaction to HIV medication

HLA-B

Variants: HLA-B*58:01 Drugs: Allopurinol Reduces risk of severe cutaneous adverse reactions to gout medication

HLA-B

Variants: HLA-B*15:02 Drugs: Carbamazepine, Oxcarbazepine, Phenytoin Reduces risk of SJS/TEN from antiepileptic drugs, especially in Asian populations

MT-RNR1

Variants: m.1555A>G Drugs: Aminoglycoside antibiotics (gentamicin, tobramycin) Prevents irreversible hearing loss (ototoxicity) from common antibiotics